Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment
نویسندگان
چکیده
منابع مشابه
Time-restricted feeding on weekdays restricts weight gain: A study using rat models of high-fat diet-induced obesity
A recent study reported that a special weekly scheduled time-restricted feeding regimen (TRF), i.e., no food consumption for 15h during the light (inactive) phase per day for 5 weekdays, attenuated the outcome of diverse nutritional challenges in response to high-fat diet in mice. In the present study, we wanted to further test whether this TRF could restrict body weight gain in both juvenile a...
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In addition to metabolic and cardiovascular disorders, obesity pandemic is associated with chronic low-grade inflammation as well as adverse cognitive outcomes. However, the existence of critical periods of development that differ in terms of sensitivity to the effects of diet-induced obesity remains unexplored. Using short exposure to a high-fat diet (HFD) exerting no effects when given to adu...
متن کاملTime-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of...
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Background: A high-fat diet (HFD) and fat accumulation promote the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. Therefore, the present study examines the potential positive effects of a restricted high-fat diet (RHFD) and antioxidants consumption on sperm parameters in rats. Methods: 48 male albino wistar rats divided to four groups (n=12...
متن کاملASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice
Although high-fat diet intake is known to cause obesity and diabetes, the effect of high-fat diet itself on cognitive function remains to be clarified. We have previously shown that apoptosis signal-regulating kinase 1 (ASK1) is responsible for cognitive impairment caused by chronic cerebral hypoperfusion. The present work, by using ASK1 deficient mice, was undertaken to explore the influence o...
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ژورنال
عنوان ژورنال: iScience
سال: 2021
ISSN: 2589-0042
DOI: 10.1016/j.isci.2021.102532